Evaluation of a screening instrument for essential tremor
Identifieur interne : 002857 ( Main/Exploration ); précédent : 002856; suivant : 002858Evaluation of a screening instrument for essential tremor
Auteurs : Delia Lorenz [Allemagne] ; Frank Papengut [Allemagne] ; Henrik Frederiksen [Danemark] ; Florian Kopper [Allemagne] ; Stephan Klebe [Allemagne] ; Kaare Christensen [Danemark] ; Stefan Schreiber [Allemagne] ; Günther Deuschl [Allemagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2008-05-15.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Archimedes spiral, Cross-Sectional Studies, Essential Tremor (diagnosis), Essential Tremor (epidemiology), Essential Tremor (genetics), Evaluation, Female, Humans, Instrument, Male, Mass Screening (methods), Medical screening, Middle Aged, Nervous system diseases, Population Surveillance (methods), Spiral, Tremor, Twins (genetics), essential tremor, screening instrument.
- MESH :
- diagnosis : Essential Tremor.
- epidemiology : Essential Tremor.
- genetics : Essential Tremor, Twins.
- methods : Mass Screening, Population Surveillance.
- Aged, Aged, 80 and over, Cross-Sectional Studies, Female, Humans, Male, Middle Aged.
Abstract
To evaluate a screening instrument for essential tremor (ET) consisting of a seven‐item questionnaire and a spiral drawing. A total of 2,448 Danish twins aged 70 years or more and a second sample aged 60 years or more (n = 1,684) from a population‐based northern German cross‐sectional study (PopGen ET) were screened for ET. Inclusion criteria were a previous diagnosis of ET, a positive answer to two or more questions of the questionnaire or a spiral rating >4 (range of scale 0–9). Three hundred thirteen of 380 positively screened and 321 negatively screened subjects were clinically examined. Definite or probable ET was diagnosed in 104 patients, possible in 86 and other tremors in 98 patients. The sensitivity of the screening instrument was 70.5%, the positive predictive value was 64.9%, the specificity was 68.2%, and the negative predictive value was 73.5%. Tremor severity correlated significantly with higher spiral scores and more positive items. More patients were identified by spiral drawing in all tremor groups. The interrater and intrarater reliability for spirals ranged from 0.7 to 0.8 using intraclass coefficient. A cluster analysis revealed that the questionnaire can be reduced to three items, about uncontrollable tremor in any body part, tremor while drinking or pouring and other family members with tremor, without loosing efficacy. We present an easy to use and reliable screening instrument that is effective to identify patients with ET but not able to exclude patients with other tremor forms. © 2008 Movement Disorder Society
Url:
DOI: 10.1002/mds.22010
Affiliations:
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A total of 2,448 Danish twins aged 70 years or more and a second sample aged 60 years or more (n = 1,684) from a population‐based northern German cross‐sectional study (PopGen ET) were screened for ET. Inclusion criteria were a previous diagnosis of ET, a positive answer to two or more questions of the questionnaire or a spiral rating >4 (range of scale 0–9). Three hundred thirteen of 380 positively screened and 321 negatively screened subjects were clinically examined. Definite or probable ET was diagnosed in 104 patients, possible in 86 and other tremors in 98 patients. The sensitivity of the screening instrument was 70.5%, the positive predictive value was 64.9%, the specificity was 68.2%, and the negative predictive value was 73.5%. Tremor severity correlated significantly with higher spiral scores and more positive items. More patients were identified by spiral drawing in all tremor groups. The interrater and intrarater reliability for spirals ranged from 0.7 to 0.8 using intraclass coefficient. A cluster analysis revealed that the questionnaire can be reduced to three items, about uncontrollable tremor in any body part, tremor while drinking or pouring and other family members with tremor, without loosing efficacy. We present an easy to use and reliable screening instrument that is effective to identify patients with ET but not able to exclude patients with other tremor forms. © 2008 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Danemark</li></country><region><li>Schleswig-Holstein</li></region><settlement><li>Kiel</li></settlement></list><tree><country name="Allemagne"><noRegion><name sortKey="Lorenz, Delia" sort="Lorenz, Delia" uniqKey="Lorenz D" first="Delia" last="Lorenz">Delia Lorenz</name></noRegion><name sortKey="Deuschl, Gunther" sort="Deuschl, Gunther" uniqKey="Deuschl G" first="Günther" last="Deuschl">Günther Deuschl</name><name sortKey="Klebe, Stephan" sort="Klebe, Stephan" uniqKey="Klebe S" first="Stephan" last="Klebe">Stephan Klebe</name><name sortKey="Kopper, Florian" sort="Kopper, Florian" uniqKey="Kopper F" first="Florian" last="Kopper">Florian Kopper</name><name sortKey="Papengut, Frank" sort="Papengut, Frank" uniqKey="Papengut F" first="Frank" last="Papengut">Frank Papengut</name><name sortKey="Schreiber, Stefan" sort="Schreiber, Stefan" uniqKey="Schreiber S" first="Stefan" last="Schreiber">Stefan Schreiber</name></country><country name="Danemark"><noRegion><name sortKey="Frederiksen, Henrik" sort="Frederiksen, Henrik" uniqKey="Frederiksen H" first="Henrik" last="Frederiksen">Henrik Frederiksen</name></noRegion><name sortKey="Christensen, Kaare" sort="Christensen, Kaare" uniqKey="Christensen K" first="Kaare" last="Christensen">Kaare Christensen</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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